Branched-Chain Amino Acids: Enzyme and Substrate Regulation
نویسندگان
چکیده
منابع مشابه
Branched-chain amino acids: enzyme and substrate regulation.
The three branched-chain amino acids (BCAAs) are the most hydrophobic of the amino acids and play crucial roles in determining the structures of globular proteins as well as the interaction of the transmembrane domains of membranous proteins with phospholipid bilayers. However, the three BCAAs do not behave identically. In terms of protein secondary structure, valine and isoleucine exhibit a de...
متن کاملBranched-Chain Amino Acids: Metabolism, Physiological Function, and Application Branched-Chain Amino Acids: Enzyme and Substrate Regulation
The three branched-chain amino acids (BCAAs) are the most hydrophobic of the amino acids and play crucial roles in determining the structures of globular proteins as well as the interaction of the transmembrane domains of membranous proteins with phospholipid bilayers. However, the three BCAAs do not behave identically. In terms of protein secondary structure, valine and isoleucine exhibit a de...
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Historically, amino acids have been viewed as precursors for protein synthesis as well as metabolic substrates. Recently, a new role for amino acids as regulators of mRNA translation has been identified. In this role, they modulate the phosphorylation state of proteins that represent important control points in translation initiation, including the translational repressor 4E-BP1 and the ribosom...
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Branched chain amino acids (BCAAs), including leucine (Leu), isoleucine (Ile), and valine (Val), play critical roles in the regulation of energy homeostasis, nutrition metabolism, gut health, immunity and disease in humans and animals. As the most abundant of essential amino acids (EAAs), BCAAs are not only the substrates for synthesis of nitrogenous compounds, they also serve as signaling mole...
متن کاملEnzymic determination of branched-chain amino acids.
Transamination of branched-chain amino acids to (alpha-oxoglutarate, catalyzed by leucine aminotransferase coupled to the glutamate dehydrogenase reaction, is used in an enzymic assay for determination of branched-chain amino acids in serum and tissue homogenates. The coefficients of variation of the method within-day and day-to-day are 2.4 and 6.5%, respectively. Analytical recovery of physiol...
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ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 2006
ISSN: 0022-3166,1541-6100
DOI: 10.1093/jn/136.1.207s